Basic Information
VIS ID
TVIS44004254
Fusion event
HTLV-1-GFRAL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
55255345/55390547 (Hg38)
End
55255345/55390547 (Hg38)
Orient
+
Location type
Intronic
Target gene
GFRAL
miRNAs that regulate target gene
hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-1253 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p
Nearest miRNA
hsa-mir-10398/Upstream/2113476; hsa-mir-10524/Downstream/1999585;
Nearest TSS
ENST00000381078/Upstream/63078; ENST00000426453/Downstream/49181;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/215953, chr6-CpG: 36/Downstream/188387
Upstream sequence
ttatggaaaagataaaaacaagcaacaagatcactcttaaatatctgcatgaatataatatatgtcctttctttcttacatttttgacaaatgcaagtca
Downstream sequence
AAGTGAGCCCAATATCAGTGGAGTAGTAAATATTGACCTCCCATAGAAAGTAGTGCTCTAggccaggcgtggtggctcacacctgtaatcccagcacttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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