Basic Information
VIS ID
TVIS44004264
Fusion event
HTLV-1-PRKG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
53857888/52098128 (Hg38)
End
53857888/52098128 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
PRKG1
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-3591-5p ; hsa-mir-1273e ; hsa-mir-921 ; hsa-mir-3606-5p
Nearest miRNA
hsa-mir-1265/Upstream/798473; hsa-mir-107/Downstream/2509746;
Nearest TSS
ENST00000439456/Upstream/51261; ENST00000467359/Downstream/199787;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/398129, chr10-CpG: 64/Downstream/216101
Upstream sequence
TAAATTTTGGTCTAATAAGGAAAAAATTTAGTTGAGAAAAAGTTCCATGCAGTTGCAAAGTTAAAAGGAAGAAAATGTTACAGTAGGTTAATTCAGCATG
Downstream sequence
TACTGAAAATACTCATTTAATAACTGAAGCAATAATCATTTCTATGTCAAGAAGATACCACAAATGTTTTTTATTATGATAATTTTCATTTCACAAAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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