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TVIS44004272
Basic Information
VIS ID
TVIS44004272
Fusion event
HTLV-1-SMURF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
62657174/64661056 (Hg38)
End
62657174/64661056 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMURF2
miRNAs that regulate target gene
hsa-mir-122-5p
;
hsa-mir-16-5p
;
hsa-mir-630
;
hsa-mir-511-5p
;
hsa-mir-203a-3p
;
hsa-mir-4670-3p
;
hsa-mir-93-3p
;
hsa-mir-382-5p
;
hsa-mir-431-5p
;
hsa-mir-526b-5p
;
hsa-mir-4635
;
hsa-mir-665
;
hsa-mir-4495
;
hsa-mir-3667-5p
;
hsa-mir-6807-5p
;
hsa-mir-6872-3p
;
hsa-mir-378a-5p
;
hsa-mir-4454
;
hsa-mir-6821-3p
;
hsa-mir-6790-3p
;
hsa-mir-3653-5p
;
hsa-mir-7107-5p
;
hsa-mir-1234-3p
;
hsa-mir-1224-3p
;
hsa-mir-186-3p
;
hsa-mir-3934-5p
;
hsa-mir-764
;
hsa-mir-125a-3p
Nearest miRNA
hsa-mir-10226/Upstream/159743; hsa-mir-1250/Downstream/119703;
Nearest TSS
ENST00000595228/Upstream/194;
ENST00000577938/Downstream/841;
Nearest CpG islands
None/Target,
chr17-CpG: 26/Upstream/153608
,
chr17-CpG: 112/Downstream/235
Upstream sequence
TCTTCTATCTGGCAACCCCTCCGGACATTCTTTTCCATTTCGAAAAAGGAATGGGGAGGGTGGGGAGAGTAACAGAAAGTTTGCTCGAAAGTTTGTATGA
Downstream sequence
GCACATACTTAGCAATGCACCCCCCCCAAAAAAGTGTGTTTTTAAAGCAGGTCTGGCGTTAGAAGTTAGACACAAGTTCTGCGGCCTAAAAGGAACAACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Sample Information
×
Sample name
ATL64
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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