Basic Information
VIS ID
TVIS44004274
Fusion event
HTLV-1-AKT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
40755166/40249259 (Hg38)
End
40755166/40249259 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
AKT2
miRNAs that regulate target gene
hsa-mir-184 ; hsa-mir-203a-3p ; hsa-mir-708-5p ; hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-1296-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-612 ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-137 ; hsa-let-7g-5p ; hsa-let-7b-5p ; hsa-mir-302b-3p ; hsa-mir-1273e ; hsa-mir-92b-5p ; hsa-mir-151b ; hsa-mir-151a-5p ; hsa-mir-3678-5p ; hsa-mir-7845-5p ; hsa-mir-4517 ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-126-3p ; hsa-mir-2861 ; hsa-mir-148a-5p ; hsa-mir-143-3p
Nearest miRNA
hsa-mir-10395/Upstream/419457; hsa-let-7e/Downstream/33284;
Nearest TSS
ENST00000633603/Upstream/5132; ENST00000600479/Downstream/5918;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/22501, chr19-CpG: 89/Downstream/35571
Nearest cancer related gene
AKT2(OG, No orient, 0)
Upstream sequence
cacaggaagtcgctgaagggttttagtcaggggggaacaggctccaaatttctgttttaagtcagtagctgctgtgtgggctacggactgggggcagtga
Downstream sequence
gaggagaccccggcatcctccaggaaagagatgctggtggcAGAGGAGACAGAGGTAAGAAAGGTACCAGTGCTGCGTGTGCCAAAGCTGCCATGGGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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