Basic Information
VIS ID
TVIS44004285
Fusion event
HTLV-1-VPS13B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
100328268/99316040 (Hg38)
End
100328268/99316040 (Hg38)
Orient
-
Location type
Intronic
Target gene
VPS13B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-186-5p ; hsa-mir-3613-5p ; hsa-mir-4494 ; hsa-mir-499b-5p ; hsa-mir-4705
Nearest miRNA
hsa-mir-12123/Upstream/922302; hsa-mir-10400/Downstream/220596;
Nearest TSS
ENST00000518652/Upstream/40831; ENST00000521037/Downstream/73576;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/302269, chr8-CpG: 35/Downstream/577389
Upstream sequence
ttttttgaatttgtttgcataggggaaggcttttacctgaagatgtatctgtcatcttggttgggttagggaactttggtgttgattctgggtgcatTAT
Downstream sequence
ATGGTGGTTTTctggtgggatgcataggttgggctagctgtggccctggtgctctggaaggcagggttgctttcagtgtcagtggtgtaggcttgcaact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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