Basic Information
VIS ID
TVIS44004291
Fusion event
HTLV-1-EPHA5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66402944/65537226 (Hg38)
End
66402944/65537226 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPHA5
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-181a-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p
Nearest miRNA
hsa-mir-12113/Upstream/4614542; hsa-mir-1243/Downstream/739598;
Nearest TSS
ENST00000502981/Upstream/512741; ENST00000509473/Downstream/132709;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2187360, chr4-CpG: 32/Downstream/132249
Upstream sequence
AATAAAAGAAGGTACTGAACAAAAATTCATTTTCAGTTGTAAGAAAATAGGATATGGGCCACTTATTTTCCAATAGATTCTTTGTAACTCAACTGAGCTT
Downstream sequence
GTCTTTACATCTAAATTGGAACATTATTGTCTTACAGTCAAGGAACAAAACTAATATGCATCACTAAGTCTTGTAGTTACTATATAACTATGTGGTGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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