Basic Information
VIS ID
TVIS44004298
Fusion event
HTLV-1-WDPCP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
63710264/63483130 (Hg38)
End
63710264/63483130 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
WDPCP
miRNAs that regulate target gene
hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6755-3p ; hsa-mir-8078 ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4716-5p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-483-5p ; hsa-mir-3977 ; hsa-mir-4279 ; hsa-mir-3157-5p ; hsa-mir-4290 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-1470 ; hsa-mir-122-3p
Nearest miRNA
hsa-mir-1301/Upstream/1277213; hsa-mir-10b/Downstream/857617;
Nearest TSS
ENST00000437798/Upstream/5196; ENST00000462944/Downstream/1559;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/423763, chr2-CpG: 69/Downstream/104936
Upstream sequence
GACACACACACAAAATTACTATTAAATTAAAATTCATTAAACTCTATCTAAAAAGGATTGTCTTTTGGGATGCTCCACTGCATATTTTAAGATGCCCGAC
Downstream sequence
ATGTTCCAATTTACCCTGTGTGATGGGTAAGGGTGGAGGCCATGAGACATGCCTCTTACTATAGGTGGCAGGCTGGCCCTCTGGTCAAATAATTCTGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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