Basic Information
VIS ID
TVIS44004309
Fusion event
HTLV-1-XPO4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
21357676/20783537 (Hg38)
End
21357676/20783537 (Hg38)
Orient
-
Location type
UTR3
Target gene
XPO4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-877-3p ; hsa-mir-18a-3p ; hsa-mir-146b-5p ; hsa-mir-16-5p ; hsa-mir-6079 ; hsa-mir-3190-3p ; hsa-mir-3165 ; hsa-mir-6880-5p ; hsa-mir-8071 ; hsa-mir-6828-5p ; hsa-mir-873-5p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4477a ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-130b-5p ; hsa-mir-16-1-3p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-100-3p ; hsa-mir-548l ; hsa-mir-548n ; hsa-mir-671-5p
Nearest miRNA
hsa-mir-4499/Upstream/349691; hsa-mir-1267/Downstream/3378879;
Nearest TSS
ENST00000623511/Upstream/9579; ENST00000422510/Downstream/119210;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/9419, chr13-CpG: 80/Downstream/119083
Upstream sequence
CATATCTGTTTGCACATATATGGAATTTCATTTTGAAAATTTTAAATCACCATTCAGAATCTAAAAGACATATATATGACAGATTGTGGCTAACACTTAA
Downstream sequence
CAGCAGAAGCTGATGCCAAGTTGACCTCTCCTGTTTCACTGTATTACATACATATCAAAGTTTCAGGCTCTCCAAAATCCAAAATGGCCAAATGAACTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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