Basic Information
VIS ID
TVIS44004329
Fusion event
HTLV-1-ADGRL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
81776627/81310942 (Hg38)
End
81776627/81310942 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
ADGRL2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-455-3p ; hsa-mir-18a-3p ; hsa-let-7i-5p ; hsa-mir-221-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/4250740; hsa-mir-11399/Downstream/3822852;
Nearest TSS
ENST00000473358/Upstream/4743; ENST00000468283/Downstream/246760;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/979741, chr1-CpG: 281/Downstream/489371
Nearby gene
LOC101927434(No orient, 202938)
Upstream sequence
TTGAAAGAAAAAAAAAAAAAAAGGGAGGAGTGGTGAGAAGAGAACAGAGGATGGTGATTTTGAGTCTGTGTTGATAGAAACATTCAATGGAGTTAAAACT
Downstream sequence
GACCTACAACCATTTGAAGAACGTGTCCCTCATTACTAAATTCTTTGGCTGTAATACTGAGCTCCCTATCTAAAAAGATGTCAATTTCCTGAAATTAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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