Basic Information
VIS ID
TVIS44004337
Fusion event
HTLV-1-LOC105378436 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
95316997/93557240 (Hg38)
End
95316997/93557240 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
LOC105378436
Nearest miRNA
hsa-mir-107/Upstream/3964413; hsa-mir-1287/Downstream/2507075;
Nearest TSS
ENST00000439456/Upstream/40033; ENST00000371481/Downstream/9425;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/60435, chr10-CpG: 93/Downstream/9232
Nearby gene
FFAR4(No orient, 9425)
Upstream sequence
TGAGTTTCTCTGGAGATTGAAGCAGTAGTCAAGTTTTTAACATAGGATTTTTTGTTTTGTTTTGTTTGTTTGTTTTTAATGACTGCCACACATACTCTGT
Downstream sequence
CCTAAAAGAAAGAGAAGTTTAACAACAGCAAAATAAGCAGGACATAATCTTGCAAGTAAAAATGGATGTGGTTAGCCTTGGGGAAAACTACACAGTTGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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