Basic Information
VIS ID
TVIS44004356
Fusion event
HTLV-1-ABCC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
48725998/50648637 (Hg38)
End
48725998/50648637 (Hg38)
Orient
-
Location type
Intronic
Target gene
ABCC3
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-192-5p ; hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-10226/Upstream/1137737; hsa-mir-1250/Downstream/120013;
Nearest TSS
ENST00000595228/Upstream/13736; ENST00000515585/Downstream/9506;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/13293, chr17-CpG: 65/Downstream/58563
Upstream sequence
aaagacctccagattcttccagttgttgggggagtcttccctaaaggaccaggttcctacttgatcactctgcagtgaagcccaacagccaataagcTTG
Downstream sequence
GTCCTCGGTACTCTGTCTTCAGTAGCTGTTTCTTGGTCCTTGGTCCTTGGTACTCTCACTCATCATTGTTCACAGATTGCCCTGAGGAGTCCCAGATCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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