Basic Information
VIS ID
TVIS44004358
Fusion event
HTLV-1-LDAH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
21001740/20801980 (Hg38)
End
21001740/20801980 (Hg38)
Orient
-
Location type
Intronic
Target gene
LDAH
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-3125/Upstream/1453475; hsa-mir-10b/Downstream/4526660;
Nearest TSS
ENST00000437798/Upstream/61989; ENST00000447260/Downstream/21109;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/130460, chr2-CpG: 30/Downstream/20824
Upstream sequence
CCTATGGTCTCTTatttcctcatattactcttctcttctcccaaattctatgtgtgtgtgtgtgtgtgtgtgtgtgtatgtgtgtgtgtgtgtgtgtatg
Downstream sequence
tatgaatatgtgtgtatatatatgtatatatacatatacatacatatccacacatactatatctatctatctatatacacacacaatatacatgtatata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate