Basic Information
VIS ID
TVIS44004359
Fusion event
HTLV-1-LOC730100 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
52588345/52361207 (Hg38)
End
52588345/52361207 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC730100
Nearest miRNA
hsa-mir-1301/Upstream/1664945; hsa-mir-10b/Downstream/341315;
Nearest TSS
ENST00000437798/Upstream/1135632; ENST00000435357/Downstream/11911;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1332847, chr2-CpG: 118/Downstream/210058
Nearby gene
MIR4431(-341315) ;
Upstream sequence
GTAAAATAATTACTTTTTTATGGTTGCTATTTCCTCAGTTGACGTTATCTCTATGAGGGCAGGAATGTTGCTTATGTTTCCAGATATAGTAATACAAATA
Downstream sequence
ATACCTATCCtataatatataataaaaaaattaCTGAGTGAATGAATGAAAAAATCAGAAAAGCTTTCATAAATTAAGGGCTGATAGTAAAGGTATAAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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