Basic Information
VIS ID
TVIS44004380
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
32216050/32214428 (Hg38)
End
32216050/32214428 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/3394760; hsa-mir-1243/Downstream/4211938;
Nearest TSS
ENST00000502981/Upstream/217031; ENST00000515181/Downstream/136610;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1491208, chr4-CpG: 100/Downstream/4029581
Upstream sequence
AAAGAAATTGGGAGGCCAGGCAGATGTGTGGTTTGTTCAATGGAACTGAATTTGAAGAACAATTAATATGATGTGGGATTGGATTGCCTACCTCCCTAAG
Downstream sequence
GACAAAATATGCCTGAAATTGCTCCTTCAAATGCGTCCTATAGGCACCATTCCGTGAGCGCACAGTGGGAGTGTCAGAGTGATTTGGGAACAAGAGCCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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