Basic Information
VIS ID
TVIS44004385
Fusion event
HTLV-1-POLK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74841924/75546099 (Hg38)
End
74841924/75546099 (Hg38)
Orient
+
Location type
Intronic
Target gene
POLK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-132-3p
Nearest miRNA
hsa-mir-10397/Upstream/2667436; hsa-mir-103a-1/Downstream/7294056;
Nearest TSS
ENST00000502646/Upstream/33961; ENST00000507073/Downstream/911;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/33950, chr5-CpG: 39/Downstream/65362
Upstream sequence
CCTTTCTTCTCTCCAAGAATATCATAATCTTGTGATAGTAcagatgacctttgaacaccacaggggctagggaccctgcccacacacaatcaaaaattca
Downstream sequence
catataatttttgactcctgaagaacgtaactactaatagcctattgtaaactggaagccttactaataaggtatacagttgattaatatgtattttgta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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