Basic Information
VIS ID
TVIS44004395
Fusion event
HTLV-1-PPP1R14C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
150501045/150179909 (Hg38)
End
150501045/150179909 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP1R14C
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-29c-3p ; hsa-mir-130a-3p ; hsa-mir-191-5p ; hsa-mir-134-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4671-3p ; hsa-mir-7114-5p ; hsa-mir-526b-3p ; hsa-mir-520e ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-4672 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-3166 ; hsa-mir-6890-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-6768-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-6757-3p ; hsa-mir-30d-5p
Nearest miRNA
hsa-mir-10398/Upstream/9496026; hsa-mir-1202/Downstream/922766;
Nearest TSS
ENST00000381078/Upstream/36833; ENST00000546121/Downstream/188983;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/36043, chr6-CpG: 124/Downstream/420001
Upstream sequence
tgtgatcttaggcaagttacttagactctgttttttggtttttctcatttgtaaggtgtgttttggggaaacagataacaaaagggatgttgtaagaatt
Downstream sequence
aactgagatgggccaggcacggtggctccggcctataattccagctgtttgggaggccgagggggatagatcacctgaggtcaggagtttgagaccagcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate