Basic Information
VIS ID
TVIS44004396
Fusion event
HTLV-1-PACRG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
GRCh37/hg19
Start
163572667/163151635 (Hg38)
End
163572667/163151635 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6E
Target gene
PACRG
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10398/Upstream/4386882; hsa-mir-1913/Downstream/3357719;
Nearest TSS
ENST00000381078/Upstream/89349; ENST00000611387/Downstream/33238;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1853, chr6-CpG: 341/Downstream/261662
Nearest cancer related gene
PACRG(TSG, No orient, 0)
Upstream sequence
CTGTGCTATGTTGTATGGAATTTCAGAGAGACATTTTATTATTTGTCCTCGATAGGAAAATGTGCAAAATCCATGGTTTGCTTATTCCAGATAGAATTAT
Downstream sequence
CTCACTTTTCTTTAAATCAGCATCAGTAAGCATGAATTCAGCCACATAAATAACTTTACTTTTAAAATCATGAATAAAAGTTGAGTTTACCCGCTAAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate