Basic Information
VIS ID
TVIS44004399
Fusion event
HTLV-1-VPS50 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
92925635/93296323 (Hg38)
End
92925635/93296323 (Hg38)
Orient
-
Location type
Intronic
Target gene
VPS50
miRNAs that regulate target gene
hsa-mir-127-5p ; hsa-mir-4650-3p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-5189-3p ; hsa-mir-4257 ; hsa-mir-6755-5p ; hsa-mir-6847-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-335-3p ; hsa-mir-4668-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-548z ; hsa-mir-3613-3p ; hsa-mir-548h-3p ; hsa-mir-548bb-3p ; hsa-mir-548d-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10525/Upstream/1092225; hsa-mir-10399/Downstream/186437;
Nearest TSS
ENST00000635602/Upstream/908; ENST00000467326/Downstream/24530;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/252621, chr7-CpG: 28/Downstream/278450
Upstream sequence
ATATTTTCTCATTTGTCTATATTAAACTCATAACCatattaaacatttattaaaattaaatatttaatttatcattaattGTGGATTTAGGCTGACTGTT
Downstream sequence
TTCTGAGTATTATGCATAAAAAGAAAGGAAAATCTTATAGTTATTGAATATACACCCAGGATCAGATATGATTTGTTTCTGACTTAGTCTCCCAATAGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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