VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004400

Fusion event

HTLV-1-STRIP2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

q32.1

Reference genome

GRCh37/hg19

Start

129094235/129454394 (Hg38)

End

129094235/129454394 (Hg38)

Orient

Location type

Intronic

Target gene

STRIP2

miRNAs that regulate target gene

hsa-mir-423-5p ; hsa-mir-4761-5p ; hsa-mir-4709-3p ; hsa-mir-4635 ; hsa-mir-100-3p ; hsa-mir-5007-3p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-4751 ; hsa-mir-1279 ; hsa-mir-944 ; hsa-mir-205-3p ; hsa-mir-4279 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-665 ; hsa-mir-887-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6514-3p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-4448 ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-3189-3p ; hsa-mir-212-5p ; hsa-mir-6736-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-4422 ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4267 ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-7706 ; hsa-mir-3934-5p ; hsa-mir-4252 ; hsa-mir-4731-5p ; hsa-mir-5089-5p ; hsa-mir-5095 ; hsa-mir-512-3p ; hsa-mir-552-3p ; hsa-mir-5589-5p ; hsa-mir-619-5p ; hsa-mir-6504-3p ; hsa-mir-6506-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-759

Nearest miRNA

hsa-mir-10525/Upstream/1246451; hsa-mir-10399/Downstream/315989;

Nearest TSS

ENST00000635602/Upstream/19948; ENST00000465033/Downstream/3848;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/19535, chr7-CpG: 100/Downstream/47936

Upstream sequence

CCATTAGGAAGTTGCCCTGTAGCTAATCTCACTGGGTTGGGCTTCCCACAGAGACCATCTCTGAGGTCTGTGACTATGGGCTGGGAATTGCCTTGGGAAC

Downstream sequence

CTCTTGTGACTCTTCTGTAACCCCAGGGTGCTGCTGAGTGTTATGTACCTAATGGTGGAAAATATTCGCCTGGAGCGAGAGACAGACCCCTGTGGGTGGA

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.