Basic Information
VIS ID
TVIS44004419
Fusion event
HTLV-1-GABRG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
46063401/46061384 (Hg38)
End
46063401/46061384 (Hg38)
Orient
+
Location type
Intronic
Target gene
GABRG1
miRNAs that regulate target gene
hsa-mir-3924 ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-567 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-654-3p ; hsa-mir-5580-3p ; hsa-mir-5011-5p
Nearest miRNA
hsa-mir-12113/Upstream/5559265; hsa-mir-1243/Downstream/1591285;
Nearest TSS
ENST00000502981/Upstream/1051844; ENST00000502455/Downstream/62697;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1334682, chr4-CpG: 65/Downstream/328502
Upstream sequence
AATATAAAAGAATGCTTTAATGAGACAAAATCATTAAGAAAATTCAAGAATATCATTAATAAAAGGCAAAAAAAAATGTGGAAATTTAGTAAGTGAAGAA
Downstream sequence
GTAGGGTTATGCTTATGAATAAAATGTCATATTACACTCTACCAAATTCTAGAATGTGATCTGTGAAAACAATAAATTTCAAAAGAAAGAAAATAGCATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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