Basic Information
VIS ID
TVIS44004439
Fusion event
HTLV-1-MIB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19376227/21796266 (Hg38)
End
19376227/21796266 (Hg38)
Orient
-
Location type
Intronic
Target gene
MIB1
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-193b-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-541-5p ; hsa-mir-374a-5p ; hsa-mir-6885-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3619-3p ; hsa-mir-3140-3p ; hsa-mir-4700-3p ; hsa-mir-335-3p ; hsa-mir-889-3p ; hsa-mir-5579-5p ; hsa-mir-590-3p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-4753-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4636 ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-3156-2/Upstream/112677; hsa-mir-1-2/Downstream/29432;
Nearest TSS
ENST00000575820/Upstream/54946; ENST00000577749/Downstream/1818;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/54288, chr18-CpG: 20/Downstream/100625
Upstream sequence
ttagacctttgtcagatgggtagattgcaaaaattttcttccagccataaaaaaagaatgagatcatgtcctttgcagggacatggatgaagctggaagc
Downstream sequence
catcatccttagcaaacaaacacagaacagaaaaccaaacaccacatgttctcactcataagtgggagttgagcaatgagaacatgtggacacagggagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate