VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004455

Fusion event

HTLV-1-ADH5 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr4

Cytoband

q23

Reference genome

GRCh37/hg19

Start

100003203/99082052 (Hg38)

End

100003203/99082052 (Hg38)

Orient

Location type

Exonic

Target gene

ADH5

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-106b-5p ; hsa-mir-218-5p ; hsa-mir-4709-3p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-4635 ; hsa-mir-873-5p ; hsa-mir-5197-5p ; hsa-mir-6510-3p ; hsa-mir-4668-5p ; hsa-mir-549a ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-4715-3p ; hsa-mir-5589-3p ; hsa-mir-6715b-5p ; hsa-mir-6872-3p ; hsa-mir-4269 ; hsa-mir-5582-5p ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-520g-5p ; hsa-mir-4282 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-1227-3p ; hsa-mir-4451 ; hsa-mir-6799-5p ; hsa-mir-4252 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-1247-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p

Nearest miRNA

hsa-mir-12113/Upstream/84592; hsa-mir-1243/Downstream/2158743;

Nearest TSS

ENST00000502981/Upstream/2029; ENST00000499178/Downstream/3164;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/85634, chr4-CpG: 43/Downstream/6533

Upstream sequence

GTGGTTCAAGTATTCTCCTTACCCGCCTTCAGCTTAGTAACTCCCTCACCAACACTTTCCACAATTCCAGCACCTTCATGTCCCAAGATCACTGGAAAAC

Downstream sequence

AACCCTCAGGATCAGCTCCACTCAGGGTATAGGCATCGGTGTGGCAAACCGCAGTGGCAATGATCTATCAGGACATTAAAACAACGAATGTGTAAGTATG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.