Basic Information
VIS ID
TVIS44004471
Fusion event
HTLV-1-GAS7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10045203/10141886 (Hg38)
End
10045203/10141886 (Hg38)
Orient
+
Location type
Intronic
Target gene
GAS7
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-1255b-5p ; hsa-mir-6744-5p ; hsa-mir-1255a ; hsa-mir-1287-5p ; hsa-mir-4487 ; hsa-mir-450b-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-3124-3p ; hsa-mir-6837-3p
Nearest miRNA
hsa-mir-1253/Upstream/1954882; hsa-mir-10226/Downstream/1940013;
Nearest TSS
ENST00000595228/Upstream/27333; ENST00000609088/Downstream/56665;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/236864, chr17-CpG: 142/Downstream/55831
Upstream sequence
agggttaaaCTTTTACATTTTCTTTAAAAATAAAGTATAATAAATGTTATTTTTGTTAAGATTAACACTTTTCAGAATAACTCTGTCAAGCTCATGGTGA
Downstream sequence
TGAGTCAGTAGGCACTGCCTAAAAAGTTGAGGATGGCATATATTAAAAAGTTACATAGTAggccgggcgcaatggctcacgcctgtaatcccagcacttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate