Basic Information
VIS ID
TVIS44004474
Fusion event
HTLV-1-TMEM131L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154447976/153526824 (Hg38)
End
154447976/153526824 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM131L
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-335-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5007-3p ; hsa-mir-5092 ; hsa-mir-3163 ; hsa-mir-513b-3p ; hsa-mir-548n ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-606 ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4724-5p ; hsa-mir-216b-5p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-12113/Upstream/990308; hsa-mir-1305/Downstream/5601978;
Nearest TSS
ENST00000502981/Upstream/60475; ENST00000462540/Downstream/27357;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/59361, chr4-CpG: 95/Downstream/157110
Upstream sequence
agactctgtctcaaaaaaaaaaaaaGGAAGCTTGCTGTCTTATATGAGGCCAGTAGCACTTGTAAATAGCTCCTGTCGTGTTGTGAAATGTGCTATAACA
Downstream sequence
GAGATAGGTGTAAAATGCTGCAGAAACACAGAGGAGGGGTAAATTGTTCTGGTAATTAAGGGTTCACATCATGTCTATTCTGTTGAGCGGGCGTGTAGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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