Basic Information
VIS ID
TVIS44004480
Fusion event
HTLV-1-CLEC16A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11166852/11072995 (Hg38)
End
11166852/11072995 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLEC16A
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/5440429; hsa-mir-11401/Downstream/233445;
Nearest TSS
ENST00000527434/Upstream/1893; ENST00000459723/Downstream/50748;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/128089, chr16-CpG: 28/Downstream/101040
Upstream sequence
AGGTAACACAGGCTTGTTAACTAGATAATAAGGTTCTTGGAAAGATGACTTTCAGGAAAGTGGGTGCCGTCTGATTGAAGAGCTGAAACCACAGGATGGG
Downstream sequence
GTGGGAACTTGAATCAGACCCAGATGGCTCCTTGGGGGCAATTTAGTTCAAGCATCCAGGCATGGGCCCTGGAGAAGCGGTTTGCTTAGTGCTGACTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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