Basic Information
VIS ID
TVIS44004485
Fusion event
HTLV-1-ASB7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
101187730/100647525 (Hg38)
End
101187730/100647525 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASB7
miRNAs that regulate target gene
hsa-mir-9-3p ; hsa-mir-6512-5p ; hsa-mir-580-5p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-3927-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-2276-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p
Nearest miRNA
hsa-mir-10393/Upstream/1863023; hsa-mir-1302-10/Downstream/1312934;
Nearest TSS
ENST00000557528/Upstream/37978; ENST00000559755/Downstream/68724;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/44593, chr15-CpG: 49/Downstream/202002
Upstream sequence
tttattatCATGTTTAATATGAAAGCAAAACTTCCTTGACTCCAAACACTACTGAAGCACAGTTGAAGAATTCTTCCTTGTTTTTGGAGCCATCTGTATT
Downstream sequence
GTTTTTGTAAAACAAAATATTCCAAAGGGAAAGAAATAGGATTTTGTGATTTTTCTTTTGAATTGAGATATAACGGGTTTTTATTGGCAAGTGATCAGGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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