Basic Information
VIS ID
TVIS44004488
Fusion event
HTLV-1-USP47 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
11906105/11884558 (Hg38)
End
11906105/11884558 (Hg38)
Orient
+
Location type
Exonic
Target gene
USP47
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-21-5p ; hsa-mir-204-5p ; hsa-mir-218-5p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-202-3p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-8066 ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-210/Upstream/101336; hsa-let-7a-2/Downstream/279125;
Nearest TSS
ENST00000527297/Upstream/4372; ENST00000525078/Downstream/53772;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/42087, chr11-CpG: 94/Downstream/123632
Upstream sequence
GTCCATAGGCACCACTGGATCATACCAGTGACAAGTCACTTCTCGACGCTAATTTTGAGCCAGGAAAGAAGAACTTTCTGCATTTGACAGATAAAGATGG
Downstream sequence
TGAACAACCTCAAATACTGCTGGTAAGCTACTTAGAAAGCCCCATATTTATAATTTTTGTGCACTGTCACCTACTACTTGAGGATGCAGTTTCCCAAAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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