Basic Information
VIS ID
TVIS44004505
Fusion event
HTLV-1-MYH15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
108134669/108415822 (Hg38)
End
108134669/108415822 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYH15
miRNAs that regulate target gene
hsa-mir-4683 ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-6888-5p ; hsa-mir-7161-3p ; hsa-mir-1207-5p ; hsa-mir-28-5p ; hsa-mir-3139 ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-4487 ; hsa-mir-4722-5p ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-6077 ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-6868-5p ; hsa-mir-708-5p ; hsa-mir-7150 ; hsa-mir-7-5p
Nearest miRNA
hsa-let-7g/Upstream/4891706; hsa-mir-12124/Downstream/1187006;
Nearest TSS
ENST00000440867/Upstream/62166; ENST00000497905/Downstream/43611;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/193166, chr3-CpG: 38/Downstream/173558
Upstream sequence
agttataaaagtcctaaggcaggagtgatggtgcctggtttaagaggcagaagggaagccagggcagctggaggggagtaaatgagggaagcagatgtag
Downstream sequence
gaagtaggtcacagaaggaggctggagccagatcaggggggcttgtaggccaattggaagTCACTGGGAAGGCAGCCAGAGAGATCTTCTAAAATATAAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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