Basic Information
VIS ID
TVIS44004519
Fusion event
HTLV-1-NFATC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77255211/79495211 (Hg38)
End
77255211/79495211 (Hg38)
Orient
-
Location type
Intronic
Target gene
NFATC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-145-5p ; hsa-mir-4755-5p ; hsa-mir-5006-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-324-5p ; hsa-mir-3124-3p ; hsa-mir-4671-5p ; hsa-mir-6832-3p ; hsa-mir-143-3p
Nearest miRNA
hsa-mir-1-2/Upstream/6641829;
Nearest TSS
ENST00000575820/Upstream/1815; ENST00000586695/Downstream/28713;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/208, chr18-CpG: 34/Downstream/469
Upstream sequence
CTCTCTAAAAATAGGGGCTGCATGGGCTGTGCACATCCCGTGTGGGTGCTGTTGCAGGTCTCCCGCCGTGGCGTGCAGGCTGTGAGGCCACAGTGCCTCC
Downstream sequence
GTCCTTCCCTGAGGTGGGCACGGGAGAAAGGAGAGGTGCCCGCTCCTGTGAGCTGCCCACGGGCTGCTCCTTGGGGCCTGTGAGGTTCTGGGCACTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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