Basic Information
VIS ID
TVIS44004527
Fusion event
HTLV-1-SLCO5A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
70700303/69788068 (Hg38)
End
70700303/69788068 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLCO5A1
miRNAs that regulate target gene
hsa-mir-192-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-548s ; hsa-mir-6873-3p ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6892-3p ; hsa-mir-6849-3p ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4684-5p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-1276 ; hsa-mir-320e ; hsa-mir-519a-3p ; hsa-mir-519b-3p ; hsa-mir-519c-3p ; hsa-mir-6128 ; hsa-mir-767-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5408811; hsa-mir-10400/Downstream/4760475;
Nearest TSS
ENST00000518652/Upstream/74678; ENST00000501104/Downstream/44647;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1456500, chr8-CpG: 224/Downstream/43795
Upstream sequence
ATCAAACCCAATATTGTTATTAGCCCATTCTTTTACCGGCTTTCTCATTTTGAATGACATTTCTGTTCTTGATTATAGGATTTTAATCTCATTAGAGTCC
Downstream sequence
TACATAACAAATCCAGAGGTAGATTTAAAAGAAAAAAATCACACAATTTCAAATTATTTCAGGAGGGCAACCCTGAGATTATTCACTAGTTCAGCAACTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate