Basic Information
VIS ID
TVIS44004544
Fusion event
HTLV-1-LOC105369844 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
76359840/75966060 (Hg38)
End
76359840/75966060 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105369844
Nearest miRNA
hsa-let-7i/Upstream/6381237; hsa-mir-1178/Downstream/3453197;
Nearest TSS
ENST00000382841/Upstream/1620; ENST00000552367/Downstream/17955;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/454322, chr12-CpG: 142/Downstream/65003
Nearby gene
PHLDA1(-59387) ;
Upstream sequence
GACTCACAACAGGTGTTCTATTTTCACCTCATGGTGAAATAGTACATTGTGTAGTAATGAAAAGAGAGTGAGAAAGGTAAGACAATGAAATATCCAGCCC
Downstream sequence
AGCAGGACAGAAGATTTGAGATTTGGCTGGTTGGAAGTTTTAGAGCAGCTGTCATATTTGAAAGACTAAGTGCACATCTCTATAAATGCACTTAGTCCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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