Basic Information
VIS ID
TVIS44004571
Fusion event
HTLV-1-ABCC8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17442192/17420645 (Hg38)
End
17442192/17420645 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
ABCC8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-136-5p
Nearest miRNA
hsa-mir-210/Upstream/1451024; hsa-let-7a-2/Downstream/967142;
Nearest TSS
ENST00000527297/Upstream/6075; ENST00000428619/Downstream/7274;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/30905, chr11-CpG: 93/Downstream/55271
Upstream sequence
AGATGCGACCAGGGCCGTCCTGAGAGAAGCCTTTTTCTCTCTTCCTGGGGAATCAGGGCTCTTGGCAGGCAGCATCCACACCAACCACCACAGGCAACAG
Downstream sequence
CATTGCAGCAGGGAGCTCCAGTGAGACTGCATGTGCAGCTCCTCACAGGGAAGTGGGAGCCTCTTCCCCACGCTGATCCTTTCCTCAGGGCCCTGGTTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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