Basic Information
VIS ID
TVIS44004584
Fusion event
HTLV-1-ADAM22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
87611581/87982266 (Hg38)
End
87611581/87982266 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM22
miRNAs that regulate target gene
hsa-mir-539-5p ; hsa-mir-451b ; hsa-mir-624-5p ; hsa-mir-5581-3p ; hsa-mir-5701 ; hsa-mir-4716-5p ; hsa-mir-6782-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-3148 ; hsa-mir-33b-3p ; hsa-mir-3692-5p ; hsa-mir-371a-3p ; hsa-mir-371b-3p ; hsa-mir-4704-5p ; hsa-mir-515-3p ; hsa-mir-519e-3p ; hsa-mir-5580-5p ; hsa-mir-570-3p ; hsa-mir-6080 ; hsa-mir-6124
Nearest miRNA
hsa-mir-10525/Upstream/12066997; hsa-mir-10399/Downstream/4221749;
Nearest TSS
ENST00000635602/Upstream/47510; ENST00000478920/Downstream/107653;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/47010, chr7-CpG: 59/Downstream/237422
Upstream sequence
gacttagacttgagaagaaaggaaacaaagactttactcttagggaatttgcatctagccagagaaacaaacaatgaacatgttaaataaggtaatttca
Downstream sequence
gagagtgacagtgccatttatagagagtgtctggtgtgaggatgaaaatagcacattcgagaattggttgtccgggacaggccatctctaaggaggtgac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate