VISDB Viral Integration Site DataBase

VIS ID

TVIS44004596

Fusion event

HTLV-1-RORA integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr15

Cytoband

q22.2

Reference genome

Start

End

61355796/61063597 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-33b-5p ; hsa-mir-129-5p ; hsa-mir-32-3p ; hsa-mir-1179 ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-let-7f-2-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-let-7a-3p ; hsa-let-7b-3p ; hsa-let-7f-1-3p ; hsa-mir-98-3p ; hsa-mir-3611 ; hsa-mir-5580-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-670-3p ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3662 ; hsa-mir-942-5p ; hsa-mir-506-5p ; hsa-mir-137 ; hsa-mir-218-5p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-4668-5p ; hsa-mir-3613-5p ; hsa-mir-4786-3p ; hsa-mir-4635 ; hsa-mir-4781-3p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-7109-3p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-758-3p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-3171 ; hsa-mir-873-5p ; hsa-mir-1246 ; hsa-mir-8076 ; hsa-mir-144-3p ; hsa-mir-101-3p ; hsa-mir-4536-5p ; hsa-mir-3924 ; hsa-mir-1277-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-621 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-3646 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-18a-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-2054 ; hsa-mir-7848-3p ; hsa-mir-4641 ; hsa-mir-656-3p ; hsa-mir-504-5p ; hsa-mir-10a-5p ; hsa-mir-10b-5p ; hsa-mir-155-5p ; hsa-mir-4775 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-483-3p ; hsa-mir-4725-5p ; hsa-mir-4750-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-377-3p ; hsa-mir-449c-3p ; hsa-mir-6740-3p ; hsa-mir-8086 ; hsa-mir-6870-3p ; hsa-mir-622 ; hsa-mir-154-3p ; hsa-mir-4643 ; hsa-mir-466 ; hsa-mir-4789-3p ; hsa-mir-485-3p ; hsa-mir-487a-3p ; hsa-mir-539-3p

Nearest miRNA

hsa-mir-10393/Upstream/1892335; hsa-mir-11181/Downstream/1241061;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/470446, chr15-CpG: 32/Downstream/163825

Upstream sequence

AATGAATTTTTGTACATTAGTATGATCAACCAACAGTGCAATAAAATGTAAAATAATATCttagaatcagattagcctgggtgaaatctttgtcctccta

Downstream sequence

aactgtatatccttggaaacacccttgaaagtttctaaaggctcagtctcttcatctttgaaatggagatatctgcctgctgaggagattagatggttca