Basic Information
VIS ID
TVIS44004601
Fusion event
HTLV-1-RDX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
110121456/110250731 (Hg38)
End
110121456/110250731 (Hg38)
Orient
+
Location type
Intronic
Target gene
RDX
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-409-3p ; hsa-let-7b-5p ; hsa-mir-331-3p ; hsa-let-7e-5p ; hsa-mir-196a-5p ; hsa-mir-196b-5p ; hsa-mir-4768-5p ; hsa-mir-6833-3p ; hsa-mir-6873-3p ; hsa-mir-7110-3p ; hsa-mir-4646-3p ; hsa-mir-4433b-5p ; hsa-mir-6826-3p ; hsa-mir-921 ; hsa-mir-6755-3p ; hsa-mir-1294 ; hsa-mir-6073 ; hsa-mir-202-3p ; hsa-mir-6795-3p ; hsa-mir-7852-3p ; hsa-mir-3174 ; hsa-mir-1244 ; hsa-mir-5683 ; hsa-mir-98-5p ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7a-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-mir-4500 ; hsa-let-7f-5p ; hsa-mir-6887-3p ; hsa-mir-3941 ; hsa-mir-6895-3p ; hsa-mir-6817-3p ; hsa-mir-6758-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4797-5p ; hsa-mir-1251-3p ; hsa-mir-1178-3p ; hsa-mir-3157-5p ; hsa-mir-3934-3p ; hsa-mir-4691-3p
Nearest miRNA
hsa-mir-10392/Upstream/6400751; hsa-let-7a-2/Downstream/1097026;
Nearest TSS
ENST00000527297/Upstream/12845; ENST00000526703/Downstream/7477;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/156780, chr11-CpG: 147/Downstream/45108
Upstream sequence
TGAAGGAGATATGGAAGCAGAAAAAAAGAATCAAGATAATCTGGCCATATGCAAGTTGGGAGGGGGTGGGGAATGGTCTTCCTACTGAAAAATGGAATAA
Downstream sequence
GTATACAGCAGATATTTAAACTGATTATAATATTTAAAACATGTTGTAGTTTACTGTACTCTGTGAGGCTCGTATCTCACATTTTATAAGAATCCTACCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate