Basic Information
VIS ID
TVIS44004615
Fusion event
HTLV-1-SLC24A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
19516640/19516642 (Hg38)
End
19516640/19516642 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC24A2
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6083 ; hsa-mir-4789-5p ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-340-5p ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4775 ; hsa-mir-29a-5p ; hsa-mir-590-3p ; hsa-mir-410-3p ; hsa-mir-4672 ; hsa-mir-6768-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4474-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3922-5p ; hsa-mir-3142 ; hsa-mir-1245b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/943263; hsa-let-7a-1/Downstream/894506;
Nearest TSS
ENST00000422679/Upstream/107583; ENST00000568063/Downstream/270286;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/107355, chr9-CpG: 91/Downstream/271575
Upstream sequence
TCGGGCATGGTTGGCCCAGGAAACCACTTTATAAGGAAATAAGACTTTAAAAACCTTTATGTCCTGACTGAATTCAGAACAGGGAGAACAGTTAGACAAC
Downstream sequence
ATCAAAGACATGACTGCTGTGGGTGATTTCTACATTTGCGAATTTGACTGGAAATTATTTTGTTTCCTTCCTAGTTGAGATTAAAATGTTGCTTTCAGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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