Basic Information
VIS ID
TVIS44004619
Fusion event
HTLV-1-AP2A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
993984/993984 (Hg38)
End
993984/993984 (Hg38)
Orient
+
Location type
Exonic
Target gene
AP2A2
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-92b-3p ; hsa-mir-331-3p ; hsa-mir-93-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-210/Upstream/425786; hsa-let-7a-2/Downstream/262621;
Nearest TSS
ENST00000527297/Upstream/8446; ENST00000526376/Downstream/2080;
Nearest CpG islands
chr11-CpG: 58/Target, None/Upstream, None/Downstream
Upstream sequence
TGCTGCGCAGCGACAGCCAGCTCAGGAACGCAGACGTGGAGCTGCAGCAGCGTGCTGTGGAGTACCTGCGGCTCAGCACCGTGGCCAGCACCGACATTCT
Downstream sequence
GGTAGGAGGCCCCCGCCCTTCGGGCTGGCTTGGCTGAGGGTTGGAGGCCAGGAGCTCTGACCAGTCCCACCCTGTGTTCTTTCCAAGGCGACCGTGCTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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