Basic Information
VIS ID
TVIS44004626
Fusion event
HTLV-1-MARVELD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68728339/69432512 (Hg38)
End
68728339/69432512 (Hg38)
Orient
+
Location type
Intronic
Target gene
MARVELD2
miRNAs that regulate target gene
hsa-mir-1244 ; hsa-mir-4293 ; hsa-mir-6849-3p ; hsa-mir-7977 ; hsa-mir-34b-5p ; hsa-mir-545-5p ; hsa-mir-449c-5p ; hsa-mir-2682-5p ; hsa-mir-3121-3p ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-621 ; hsa-mir-6516-5p ; hsa-mir-550b-2-5p ; hsa-mir-455-3p ; hsa-mir-7847-3p ; hsa-mir-1227-3p ; hsa-mir-6880-5p ; hsa-mir-6799-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-4252 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6134 ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-1247-3p ; hsa-mir-1179 ; hsa-mir-5692a ; hsa-mir-20b-3p ; hsa-mir-2114-5p ; hsa-mir-3662 ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4649-3p ; hsa-mir-5588-3p ; hsa-mir-5690 ; hsa-mir-665 ; hsa-mir-6746-5p ; hsa-mir-6771-5p ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-873-5p ; hsa-mir-940
Nearest miRNA
hsa-mir-10397/Upstream/9728809; hsa-mir-103a-1/Downstream/2736955;
Nearest TSS
ENST00000502646/Upstream/13126; ENST00000396442/Downstream/53100;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16819, chr5-CpG: 164/Downstream/59812
Upstream sequence
ttacaggtttgagccaccccacctgATCTTCTTCCTCATTTTCTAAGAATGAATTCAGAGGGTTTTTTTCTACTTATGTTTATTAACAAATCCTCTTTTT
Downstream sequence
CTCCCTAACTGCAGTGTGAAATGGCCACCAGTGGTGACAGACAAAGAGACTCAGAAGTTAATTTCAAGGAACTGAGAACAGCAAAAATGAAACCTGAACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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