Basic Information
VIS ID
TVIS44004633
Fusion event
HTLV-1-ARHGAP42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100642763/100772032 (Hg38)
End
100642763/100772032 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP42
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-28-5p ; hsa-mir-222-3p ; hsa-mir-138-5p ; hsa-mir-376c-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-4299 ; hsa-mir-3692-5p ; hsa-mir-4633-3p ; hsa-mir-6071 ; hsa-mir-6500-5p ; hsa-mir-587 ; hsa-mir-6131 ; hsa-mir-3185 ; hsa-mir-133a-5p ; hsa-mir-93-3p ; hsa-mir-885-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4511
Nearest miRNA
hsa-mir-10392/Upstream/4430506; hsa-let-7a-2/Downstream/747788;
Nearest TSS
ENST00000527297/Upstream/1666; ENST00000525558/Downstream/67372;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/84362, chr11-CpG: 170/Downstream/355267
Upstream sequence
aagattcacatttctaatagatttgaaagtaatgtccacactgctagtccatggaccacgctctgagaagcagggatttgtaatccccttcatacctctc
Downstream sequence
cacaatcacattcctcttcttcctctgcccTTTCTTTTTCTTGTATAGTTCTACCAGTTATGTCTGTATTTCTAGACGGTATGTTTTATTAGCTTTGACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate