Basic Information
VIS ID
TVIS44004637
Fusion event
HTLV-1-GABRB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
GRCh37/hg19
Start
27013784/26768637 (Hg38)
End
27013784/26768637 (Hg38)
Orient
-
Location type
Intronic
Target gene
GABRB3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-125b-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-3177-5p ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-552-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-3678-3p ; hsa-mir-1273h-3p ; hsa-mir-6802-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-298 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-4691-3p ; hsa-mir-497-3p ; hsa-mir-424-3p ; hsa-mir-4703-3p ; hsa-mir-520d-5p ; hsa-mir-524-5p
Nearest miRNA
hsa-mir-1268a/Upstream/919812; hsa-mir-10393/Downstream/1657854;
Nearest TSS
ENST00000557528/Upstream/1401; ENST00000555060/Downstream/3693;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/98031, chr15-CpG: 174/Downstream/3108
Upstream sequence
CTCTTCATCTATCTACTCAACACATTTATTGTTCCCTAGAACCACTGGTAAGCACCAAAATTATAACACACACAGTAATTTTCAGCAGACAGTGTTATTG
Downstream sequence
GACATACGCAATCTCACTTATAGAAATATACAAACTAAATCTCAATAATTATCTAGCCGTGTATAATTTTTATAGATTATCTAAAATTTTAAACAGGGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate