Basic Information
VIS ID
TVIS44004642
Fusion event
HTLV-1-ADGRE5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14495033/14384221 (Hg38)
End
14495033/14384221 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ADGRE5
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-484 ; hsa-mir-126-3p ; hsa-mir-1321 ; hsa-mir-2392 ; hsa-mir-3134 ; hsa-mir-3165 ; hsa-mir-3605-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-5586-3p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7106-5p ; hsa-mir-7515 ; hsa-mir-8071
Nearest miRNA
hsa-mir-10395/Upstream/310742; hsa-let-7e/Downstream/145322;
Nearest TSS
ENST00000633603/Upstream/2777; ENST00000591737/Downstream/12029;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/50449, chr19-CpG: 50/Downstream/21693
Upstream sequence
GAGGAACTAGCCAAGCCTTGTGGCCAGAGAGGAGGAAGAGGGGAATCCTGACAGAAGTGGGGAGTACGGGCTTGGGCTGGGGGGTTTCGGCCTTGGTTTA
Downstream sequence
ACCCAGCTGGAAGGAGTGTGGAGGTGGGAGTGGGGATCTCTGCCTTCCACCCACCTAAGGGGTACTAAATTTGAACACAGTGGCTGAGTGGTCCGGGGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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