Basic Information
VIS ID
TVIS44004647
Fusion event
HTLV-1-HGF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
81360451/81731135 (Hg38)
End
81360451/81731135 (Hg38)
Orient
+
Location type
Intronic
Target gene
HGF
miRNAs that regulate target gene
hsa-mir-199a-3p ; hsa-mir-26a-5p ; hsa-mir-16-5p ; hsa-mir-26b-5p ; hsa-mir-200a-3p
Nearest miRNA
hsa-mir-10525/Upstream/5815866; hsa-mir-10399/Downstream/10472880;
Nearest TSS
ENST00000635602/Upstream/543345; ENST00000454066/Downstream/31861;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/119743, chr7-CpG: 161/Downstream/711570
Upstream sequence
TTTCATCTAAACACCTCTCTCATACAAACCATTTCTACCTTATGTAGTTAGTTGAATGCTTTATTTCATTGCATTCTATGAGCTAACCTAGGCAAACTAA
Downstream sequence
ACAATAGCTTATGTTTAGAGTTATTCTACGAAGCTTTGTGAAGAAAGGGAAAACATTACCTTAATGACTACCCTAATTACTGAAATAAGTTGTACTGTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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