Basic Information
VIS ID
TVIS44004676
Fusion event
HTLV-1-TTC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
38181104/37711899 (Hg38)
End
38181104/37711899 (Hg38)
Orient
-
Location type
Intronic
Target gene
TTC6
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-208a/Upstream/759508; hsa-mir-1185-1/Downstream/10049096;
Nearest TSS
ENST00000550708/Upstream/89834; ENST00000554555/Downstream/60484;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/88928, chr14-CpG: 43/Downstream/496050
Upstream sequence
GCAAAGATGATATCACAGGACTCAGTTGAGAGAAGATACAGTGAACAGGAGAGACATCATGGAGGGAGAATGAACAGAAATAGTCATTACTGTTGGGAGT
Downstream sequence
GAGGAAGAGATTGGTGATGAAGAGATTTTCAGTCTGAACCACTGAGATAGTGGTGTTTTTCAAAGAGAACTCTAGAAAGGGTTCGTTCTTTTCTCTGGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate