Basic Information
VIS ID
TVIS44004685
Fusion event
HTLV-1-PGBD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
249195378/248901179 (Hg38)
End
249195378/248901179 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
PGBD2
Nearest miRNA
hsa-mir-101-1/Upstream/74736;
Nearest TSS
ENST00000473358/Upstream/42015; ENST00000462488/Downstream/5017;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/27368, chr1-CpG: 80/Downstream/4874
Nearby gene
PGBD2(+5064) ;
Upstream sequence
ggaaatcagagaggacacaaacaaatgggaaaacattccatgctcagggataggaagaatcaatattgtgaaaatggccatattgcccaaactaatttat
Downstream sequence
agattcaatgctattcctattaaattgctatggacatttttcacagaaataaaaaaatatattttaaatttcatatggaaccaaaaaaaagtcctaatag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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