Basic Information
VIS ID
TVIS44004695
Fusion event
HTLV-1-TMEM45A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
100288113/100569269 (Hg38)
End
100288113/100569269 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM45A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-98-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/604871; hsa-mir-12124/Downstream/2954764;
Nearest TSS
ENST00000440867/Upstream/345; ENST00000488904/Downstream/1761;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/76538, chr3-CpG: 72/Downstream/139956
Upstream sequence
GTGCCTCAGCTGTGCCTCTGATGCTCACATTTCCCTTCATCACACTCCTCTGTGCCTCCATGTCTCCACATATGCTATTTCCTCTTCTCTCTTCTGAATG
Downstream sequence
GTTTCCCTCACCCTGCACTGCCTATAGTGAGTCCTCCATTTACCCATGTGTAGATACTTCAATTATAGCACTTCTTAAGCTTCGAGTCCTTTTTTGACCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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