Basic Information
VIS ID
TVIS44004697
Fusion event
HTLV-1-SGK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
134534163/134213025 (Hg38)
End
134534163/134213025 (Hg38)
Orient
+
Location type
Intronic
Target gene
SGK1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-100-3p ; hsa-mir-6079 ; hsa-mir-374a-3p ; hsa-mir-548aw ; hsa-mir-361-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4641 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-125a-3p ; hsa-mir-873-5p ; hsa-mir-552-3p ; hsa-mir-4803 ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-5692a ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-3942-3p ; hsa-mir-5682 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-570-3p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-6871-3p ; hsa-mir-6507-5p ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-548c-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-6809-3p ; hsa-mir-3180-5p ; hsa-mir-4639-5p ; hsa-mir-4753-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-2115-5p ; hsa-mir-4738-5p ; hsa-mir-4302 ; hsa-mir-648 ; hsa-mir-576-3p ; hsa-mir-5571-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-3650 ; hsa-mir-133b
Nearest miRNA
hsa-mir-10398/Upstream/2097762; hsa-mir-1202/Downstream/766313;
Nearest TSS
ENST00000381078/Upstream/35120; ENST00000440090/Downstream/17442;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/36407, chr6-CpG: 21/Downstream/104634
Nearest cancer related gene
SGK1(OG, No orient, 0)
Upstream sequence
CTTGTGAATGATTATCACTATTTGTTCAATAAAATCTTCCCCACGTTGAAGCTGCTCCTGATGAAGTCAGGGTCTTCAAGAATTCTTGTTCTCTGTGTCA
Downstream sequence
TTATCATACAAGTATCACACCATTCTTTATGGTTCTCAAGAACCAAAGCATCCGCGGCAAATTACCCGGAGAGCTCATATAGTAAATTTTAAGCACAAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate