Basic Information
VIS ID
TVIS44004705
Fusion event
HTLV-1-GRID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
93991905/93070754 (Hg38)
End
93991905/93070754 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
GRID2
miRNAs that regulate target gene
hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-448
Nearest miRNA
hsa-mir-12113/Upstream/5770171; hsa-mir-1243/Downstream/5926633;
Nearest TSS
ENST00000502981/Upstream/231912; ENST00000512631/Downstream/14232;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/764898, chr4-CpG: 112/Downstream/757590
Upstream sequence
TATGAGTTTTGATAGTTGCTATAAAATAAATAGAATAGCCATTTAAGTTCATTTTAAACCAAAATACATTCTTCTGCCAATTTTAAAATTATCTAAAATA
Downstream sequence
TATCTTATTACAAGATCATTTTAGTCAAATAAAACTTTAGGCACTTTTGAAATGAATGTTTACAGAATAAACAGGCAACAGACTGTACTTGATATATCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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