Basic Information
VIS ID
TVIS44004709
Fusion event
HTLV-1-HTR7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
GRCh37/hg19
Start
92543825/90784068 (Hg38)
End
92543825/90784068 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
HTR7
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7850-5p ; hsa-mir-4529-3p ; hsa-mir-4520-2-3p ; hsa-mir-4520-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-1290 ; hsa-mir-3156-3p ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-4301 ; hsa-mir-490-5p ; hsa-mir-1246 ; hsa-mir-5580-3p ; hsa-mir-532-3p
Nearest miRNA
hsa-mir-107/Upstream/1191241; hsa-mir-1287/Downstream/5280247;
Nearest TSS
ENST00000439456/Upstream/160457; ENST00000277882/Downstream/73630;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/946033, chr10-CpG: 137/Downstream/72995
Upstream sequence
TTCTAGAACATTTAGTTCTTGACAGCTACAATACAATTATACAAAGAAAGATGGGGATTAATTACATTCTTACTAAAACAAGTCATATTAAGTAGATGAT
Downstream sequence
GTGGAATAGTATAACATTTTATACATTATCTGTCACAAAATACACCACATACAAAACTCTCTAATCATGATGCCAGCCAGCTGCCAGCCAGCTGAGGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate