Basic Information
VIS ID
TVIS44004717
Fusion event
HTLV-1-chr21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17438180/16065860 (Hg38)
End
17438180/16065860 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/2341586; hsa-let-7c/Downstream/473229;
Nearest TSS
ENST00000624081/Upstream/137564; ENST00000602935/Downstream/4662;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/335376, chr21-CpG: 138/Downstream/1446628
Nearby gene
MIR99AHG(No orient, 4662)
Nearest cancer related gene
MIR99AHG(OG, No orient, 4662)
Upstream sequence
TTTATCACAGTTTATccatttaggtaatctaggaaaatctccctattttaatgtcaactgattagcaaccttaattccatcaggatccttaattatcctt
Downstream sequence
tgctacataatgtaatatatgcagtttctagggatcaggatgtggaaaattttggaggaccatctatctgtcacctaagaggaaataactcagaagaggc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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