Basic Information
VIS ID
TVIS44004727
Fusion event
HTLV-1-OGG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
9820439/9778755 (Hg38)
End
9820439/9778755 (Hg38)
Orient
-
Location type
Intronic
Target gene
OGG1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-1260b ; hsa-mir-6824-5p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5092 ; hsa-mir-1178-5p ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-4790/Upstream/4528500; hsa-let-7g/Downstream/501596;
Nearest TSS
ENST00000440867/Upstream/8763; ENST00000479956/Downstream/9328;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/28428, chr3-CpG: 86/Downstream/13553
Nearby gene
TADA3(-1209) ;
Upstream sequence
caacaagaagtggaactctcctctcagcatccacagagcaatcttatggagggcctcgagtgacccagcttgggttacatgcctgcttctgggactaatc
Downstream sequence
attgtggctagagggattggcacttgactggccaagctggggtcatgtgtgcaccctagtttggcagttggacaagaaccatgtgtgatggggaaggaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate